Career

 

Technische/n Assistent/in (BTA, CTA, MTA, PTA)
Vollzeit
Einrichtung: Gene Center and Department of Biochemistry
Besetzungsdatum: ab sofort
Ende der Bewerbungsfrist: 30.06.2017
Entgeltgruppe: TV-L
Befristung: drei Jahre
Es besteht grundsätzlich die Möglichkeit der Teilzeitbeschäftigung.
Die Ludwig-Maximilians-Universität München ist eine der größten und renommiertesten Hochschulen Deutschlands. 
Aufgaben
Sie arbeiten im spannenden Arbeitsgebiet der Erforschung der Funktionsweise des angeborenen Immunsystems und wenden eine Vielzahl an zellbiologischen, molekularbiologischen, biochemischen, genetischen und tierexperimentellen Methoden an. Dazu gehören unter anderem Zellkultur (Isolation von primären Zellen, Passagieren von Zelllinien, Herstellung von knockout Zelllinien mittels der CRISPR/Cas9 Technologie), molekularbiologische Tätigkeiten (Klonierung, PCR und Mutagenese), Durchführung von Kleintierexperimenten, Herstellung von Lentiviren zur lentiviralen Transduktion sowie biochemische Untersuchungen (Proteinexpression und Proteinaufreinigung).
Anforderungen
- Berufsabschluss als BTA, CTA, MTA, PTA oder vergleichbare Qualifikation
- Ausbildung in zellbiologischen, molekularbiologischen, tierexperimentellen und biochemischen Arbeitsmethoden und deren selbständige Durchführung
- Sehr gute Deutsch- und Englischkenntnisse
- Selbständige Arbeitsweise
Ihr Arbeitsplatz befindet sich am Genzentrum der LMU auf dem Campus Großhadern und ist gut mit öffentlichen Verkehrsmitteln erreichbar. Wir bieten Ihnen eine interessante und verantwortungsvolle Tätigkeit in einem jungen und internationalen Team mit guten Weiterbildungs- und Entwicklungsmöglichkeiten.
Die Vergütung erfolgt nach TV-L in Abhängigkeit von Ihrer Qualifikation und Erfahrung. Die Stelle ist zum nächstmöglichen Zeitpunkt zu besetzen und zunächst auf 3 Jahre befristet; wir streben jedoch eine langfristige Zusammenarbeit an.
Die Ludwig-Maximilians-Universität München setzt sich für die Gleichberechtigung ein. Schwerbehinderte Bewerber/innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt eingestellt.
Weitere Informationen
www.hornung.genzentrum.lmu.de.
Bewerbungsadresse 
Ludwig Maximilians Universität
Prof. Dr. Veit Hornung
Feodor-Lynen-Straße 25
81377 Munich 
Germany
Wir freuen uns auf Ihre Bewerbung mit den üblichen Unterlagen (Lebenslauf, Ausbildungsnachweise, Zeugnisse). Bitte bündeln Sie diese in ein PDF-Dokument und senden es (ausschließlich per Email) bis 30.06.2017 an: hornung.office@genzentrum.lmu.de 
Ansprechpartner/in 
Assistentin Frau Ginkel
Email: ginkel@genzentrum.lmu.

Technische/n Assistent/in (BTA, CTA, MTA, PTA)

Vollzeit

Einrichtung: Gene Center and Department of Biochemistry
Besetzungsdatum: ab sofort
Ende der Bewerbungsfrist: 30.06.2017
Entgeltgruppe: TV-L
Befristung: drei Jahre

Es besteht grundsätzlich die Möglichkeit der Teilzeitbeschäftigung.

Die Ludwig-Maximilians-Universität München ist eine der größten und renommiertesten Hochschulen Deutschlands. 

Aufgaben

Sie arbeiten im spannenden Arbeitsgebiet der Erforschung der Funktionsweise des angeborenen Immunsystems und wenden eine Vielzahl an zellbiologischen, molekularbiologischen, biochemischen, genetischen und tierexperimentellen Methoden an. Dazu gehören unter anderem Zellkultur (Isolation von primären Zellen, Passagieren von Zelllinien, Herstellung von knockout Zelllinien mittels der CRISPR/Cas9 Technologie), molekularbiologische Tätigkeiten (Klonierung, PCR und Mutagenese), Durchführung von Kleintierexperimenten, Herstellung von Lentiviren zur lentiviralen Transduktion sowie biochemische Untersuchungen (Proteinexpression und Proteinaufreinigung).

Anforderungen

- Berufsabschluss als BTA, CTA, MTA, PTA oder vergleichbare Qualifikation

- Ausbildung in zellbiologischen, molekularbiologischen, tierexperimentellen und biochemischen Arbeitsmethoden und deren selbständige Durchführung

- Sehr gute Deutsch- und Englischkenntnisse

- Selbständige Arbeitsweise

Ihr Arbeitsplatz befindet sich am Genzentrum der LMU auf dem Campus Großhadern und ist gut mit öffentlichen Verkehrsmitteln erreichbar. Wir bieten Ihnen eine interessante und verantwortungsvolle Tätigkeit in einem jungen und internationalen Team mit guten Weiterbildungs- und Entwicklungsmöglichkeiten.

Die Vergütung erfolgt nach TV-L in Abhängigkeit von Ihrer Qualifikation und Erfahrung. Die Stelle ist zum nächstmöglichen Zeitpunkt zu besetzen und zunächst auf 3 Jahre befristet; wir streben jedoch eine langfristige Zusammenarbeit an.

Die Ludwig-Maximilians-Universität München setzt sich für die Gleichberechtigung ein. Schwerbehinderte Bewerber/innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt eingestellt.

Weitere Informationen

www.hornung.genzentrum.lmu.de.

Bewerbungsadresse 

Ludwig Maximilians Universität
Prof. Dr. Veit Hornung
Feodor-Lynen-Straße 25
81377 München
Deutschland

Wir freuen uns auf Ihre Bewerbung mit den üblichen Unterlagen (Lebenslauf, Ausbildungsnachweise, Zeugnisse). Bitte bündeln Sie diese in ein PDF-Dokument und senden es (ausschließlich per Email) bis 30.06.2017 an: hornung.office@genzentrum.lmu.de 

Ansprechpartner/in 

Assistentin Frau Ginkel

Email: ginkel@genzentrum.lmu.de

 


 

PhD position in algorithmic bioinformatics

The Canzar lab at the Gene Center of the University of Munich (LMU) is recruiting a PhD student in algorithmic bioinformatics, to start in spring/summer 2017. The position provides a competitive salary for a period of 4 years.

We develop algorithms for the analysis of high-throughput sequencing data like (single-cell) RNA-seq as well as for third-generation technologies like PacBio and Oxford Nanopore. Supporting the lab's agenda, the successful candidate will use tools and techniques from large-scale optimization and machine learning to develop and engineer efficient algorithms that leverage large numbers of publicly available sequencing data sets. Translated into scalable and usable software, they will facilitate the systematic exploration of important biological or biomedical questions, such as the functional impact of alternative splicing.

The Canzar lab is embedded in the stimulating, interdisciplinary environment of the Graduate School for Quantitative Biosciences Munich (QBM), which integrates approaches ranging from bioinformatics and theoretical biophysics to molecular systems biology. The lab is housed in the new Research Center for Molecular Biosystems (BioSysM) at the life sciences campus Grosshadern/ Martinsried, with excellent access to other parts of Munich via public transport.

We are seeking motivated candidates with an excellent Master’s degree (or equivalent) in computer science, (applied) mathematics, or bioinformatics to join our lab. We expect the candidate to have a solid background in algorithm design and good programming skills as well as an interest in interdisciplinary work (biology, medicine).

To apply, please send your application materials, including a motivation letter, your CV, and names of two referees in a single pdf file to Stefan Canzar (stefan.canzar@lmu.de), who can also supply further information about this position. For more information about our lab at LMU, please visit our website at https://canzarlab.github.io/.

Applications will be reviewed starting from April 24, 2017

 

 


 

 

The Faculty of Chemistry and Pharmacy invites applications for a

Full Professor (W3) in Computational Biology/Biochemistry


commencing as soon as possible.

To strengthen its research focus in molecular systems biology, the Faculty of Chemistry and Pharmacy and the Gene Center of the LMU Munich seek an internationally renowned computational biologist with an interest in questions of gene regulation, genome and RNA biology, or immunology. The successful candidate will complement existing expertise in structural biology, experimental systems biology and immunology at the Gene Center and should have a strong track record in the analysis of high-dimensional biological data and in modelling complex biological systems, using a range of statistical, mathematical, and bioinformatics approaches. The candidate should have a profound interest in collaborating with experimentalists and in interdisciplinary interaction with life scientists at the Gene Center and surrounding institutions. The newly established group will be housed in the new Research Center for Molecular Biosystems and encouraged to actively participate in local research networks such as international graduate schools, national clusters of excellence, and collaborative research centers.

Prerequisites for this position are a university and a doctoral degree, demonstrated teaching skills at university level, outstanding academic achievements and a productive and internationally recognized research program.

LMU Munich provides newly appointed professors with various types of support, such as welcoming services and assistance for dual career couples.

LMU Munich is an equal opportunity employer. The University continues to be very successful in increasing the number of female faculty members and strongly encourages applications from female candidates. Information concerning equality of treatment may be obtained from the women's representative of the faculty (Regina.de_Vivie@cup.uni-muenchen.de). Furthermore, disabled candidates with essentially equal qualifications will be given preference.

Please submit your application comprising a curriculum vitae, documentation of academic degrees and certificates, summary of teaching activities, as well as a list of publications and invited lectures, a research summary, and three to five relevant publications in electronic form as a single pdf-file to the Dean of the Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-Universität (LMU), Butenandtstr. 5-13, Haus F, D-81377 Munich, Germany, email: dekanat@cup.uni-muenchen.de, no later than 12 March 2017.

 

 


 
The Hornung laboratory at the Gene Center of the Ludwig-Maximilians Universität Munich is seeking applications from

POSTDOCTORAL RESEARCH FELLOWS


for a 4-year project funded by the European Research Council (ERC)

BACKGROUND: In our research projects, we are trying to understand what mechanisms are employed by our innate immune system to distinguish self from non-self. Central to this complex task is a repertoire of pattern recognition receptors (PRRs) that have evolved to detect the presence of microorganisms. The ligands or targets of these PRRs are usually referred to as pathogen-associated molecular patterns (PAMPs). PAMPs are typically molecular structures that are unique to the physiological processes of microorganisms but not the host. In addition, PAMPs usually constitute products that are essential to microorganisms and thus cannot be changed or lost by the respective microorganism via adaptive evolution. In addition to the recognition of PAMPs, some PRRs can also detect endogenous danger and stress situations. Cell stress or tissue damage can lead to the release of normally compartmentalized molecules or the chemical modification of self-molecules. These and other endogenous inflammatory signals that appear after cellular damage or due to metabolic derangements are collectively known as danger-associated molecular patterns (DAMPs), and their ability to trigger inflammation is mediated by the PRRs of our innate immune system.

OUR RESEARCH FOCUS: Within this field, we mainly focus on two main research areas to understand: (1) the mechanisms and effector functions of intracellular nucleic acid sensing (e.g. cGAS/STING and RIG-I) and (2) the mechanisms of inflammasome activa-tion and signaling at the molecular and cellular level. To study these pathways, we employ hypothesis-driven, candidate gene knockout approaches, as well as genome-wide, unbiased screening campaigns.

YOUR QUALIFICATIONS: The successful candidate will have a PhD or equivalent in biology, biochemistry, biotechnology, medicine, veterinary medicine or related fields, ideally with post-doctoral training; possess a good work ethic; be highly motivated; able to work independently and collaboratively with colleagues from different disciplines.

OUR OFFER: The appointee will join a multidisciplinary team within a stimulating atmos-phere with excellent scientific working conditions and access to state-of-the-art instru-mentation at the Gene Center of the LMU Munich. We offer a very attractive long-term funded postdoc position (48 months). Salary is determined by experience and family status according to the German TVL-13 Scheme.

APPLICATION: General enquiries can be directed to Prof. Veit Hornung, or visit www.hornung.genzentrum.lmu.de for further information.
Please send written applications including CV, contact details of two professional referees, cover letter describing why you want to join our team, and copies of relevant certificates as a single PDF to hornung.office@genzentrum.lmu.de. Applications close January 31st 2017.

The University of Munich is an equal opportunity employer. The University welcomes and encourages interest from handicapped candidates.

 

 


 

PhD-Position (65% TV-L E13)

Structural biochemistry of proteins in the c-di-AMP pathway

 

FIELD OF WORK
We aim to structurally analyse processes involved in the bacterial c-di-AMP signalling pathway. C-di-AMP is the only known essential bacterial second messenger so far and occurs in a variety of bacteria, lots of them being pathogenic. The levels of c-di-AMP in the cells need to be tightly regulated, as changes in concentration lead to dramatic effects for the viability of the cells and also susceptibility against antibiotics. This renders c-di-AMP signalling an interesting target for antimicrobial therapy.     
The designated project is aimed to structurally and biochemically analyse proteins in c-di-AMP degradation steps. Besides biochemical and biophysical methods we use X-ray crystallography, Small-angle X-ray Scattering and (if applicable) (cryo-) Electron microscopy for the structural analysis of proteins and complexes.


YOUR PROFILE
We are looking for talented individuals who are excited about research in a competitive area. The applicant should hold an excellent Masters’ or Diploma degree in biochemistry, biophysics or a related area. Previous experience in molecular biology, protein expression, purification and characterization, or application of biophysical/structural methods is a plus.

OUR OFFER
We offer a stimulating atmosphere in the Gene Center of the LMU Munich with excellent scientific working conditions and access to state-of-the-art instrumentation. The position is embedded into the  Priority Programme “Nucleotide Second Messenger Signaling in Bacteria” funded by the German Research Council (DFG Schwerpunktprogramm 1879 ). The PhD-student can additionally be associated to the GRK1721 research training group (further information on the GRK1721 see: www.grk1721.genzentrum.lmu.de)
The position is initially funded for 36 months. The Ludwig-Maximilians-Universität München is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference. Your application should be send in one single PDF file (containing a letter of motivation, your CV / Transcript of Records and contact details of two references) to witte@genzentrum.lmu.de

Contact:
Dr. Gregor Witte    
Gene Center, LMU Munich    
email: witte@genzentrum.lmu.de    
web: http://www.grk1721.genzentrum.lmu.de/gregor-witte

 


 

In der Abteilung Virologie des Max-von-Pettenkofer-Instituts der LMU München,
in der AG Conzelmann am Genzentrum, Campus Großhadern, ist baldmöglichst die Stelle einer/s

Technischen Assistenten/in in der Forschung

(BTA, CTA oder vergleichbare Qualifikation)

 

in Vollzeit zu besetzen. Die Einstellung erfolgt zunächst befristet im Rahmen einer Elternzeitvertretung. Die Vergütung erfolgt gemäß TV-L.

In der Arbeitsgruppe werden Untersuchungen zur Molekular- und Zellbiologie von RNA Viren durchgeführt. Wir suchen eine/n aufgeweckte/n Mitarbeiter/in mit Interesse für moderne gentechnische, proteinbiochemische, zell- und systembiologische Arbeiten. Zu Ihren Aufgaben gehört die Durchführung und Dokumentation von experimentellen Arbeiten und die Unterstützung von Mitarbeitern im Labormanagement. Gute Kenntnisse der englischen Sprache, Kommunikationsfähigkeit und Umgang mit EDV-Anwendungen sind ebenso gefordert wie ein hohes Maß an Leistungsbereitschaft und Selbständigkeit.

Ihr attraktiver Arbeitsplatz befindet sich auf dem Campus München-Großhadern (Genzentrum, Feodor-Lynen-Str. 25, D-81377 München) und ist gut mit öffentlichen Verkehrsmitteln zu erreichen. Schwerbehinderte Bewerber/innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt.

Wenn Sie gerne in einem engagierten Team zielstrebig und verantwortungsbewusst arbeiten, richten Sie bitte Ihre aussagekräftige Bewerbung per Email an Prof. K.K. Conzelmann: conzelmann@genzentrum.lmu.de.

 


 

PhD student positions (TV-L E13, 65%)
and 1 Postdoctoral position (TV-L E13):
Research Training Group 1721 in Munich

 

The interdisciplinary and interfaculty DFG Research Training Group 1721 offers positions in participating research groups to pursue doctoral projects in the areas of structural protein science, advanced imaging methods and structure-function-system analysis of macromolecular complexes. Participating research groups are located at the Ludwig-Maximilians-Universität München (Gene Center, Faculty of Biology and Faculty of Chemistry), the Technische Universität München (Faculty of Chemistry) and the Max Planck Institute of Biochemistry.

The GRK1721 is a unique and competitive training and research network to study structure and mechanisms of “complex macromolecular systems” in genome biology. Research within the GRK1721 integrates state-of-the-art structural and functional biology approaches with an emphasis on the further development of structural biology “hybrid methods”.

PhD student positions (TV-L E13, 65%)


We offer challenging and interdisciplinary PhD projects and an innovative credit-based training and mentoring program in the following research areas:

Cryo-electron microscopy, x-ray crystallography, structural and cellular biochemistry, structural proteomics, hybrid methods, single-molecule analysis, chemical and synthetic biology, cell biology, super-resolution microscopy, solid-state NMR and biophysical chemistry.

Applicants to the PhD program are required to hold a German university Diploma or Master's degree (or equivalent) in biology, biochemistry, bioinformatics, biophysics, biotechnology or in a related discipline. All courses, lectures and seminars at the GRK1721 are held in English. Thus, selected candidates have to be fluent in written and spoken English.

1 Postdoctoral position (TV-L E13)


The GRK1721 is also looking for a highly motivated and talented postdoctoral candidate working at the Ludwig-Maximilians-Universität München (Gene Center). He/she should have a strong interest in method development and will work on hybrid approaches combining mass spectrometry and structural biology.

Please send your complete applications in English as a single PDF (CV, motivation statement and research experience, record of study, certificates and contact information of two referees) to grk1721@genzentrum.lmu.de. The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference. The doctoral positions and the postdoctoral position are limited to 3 and 2 years, respectively.

Deadline for application is 30 July 2016.
Further information is available on the GRK1721 website: http://www.grk1721.genzentrum.lmu.de/application/

 


 

PhD Position in Computational Genomics

 

The Canzar lab at the Gene Center of the University of Munich (LMU) is recruiting graduate students in Computational Genomics, to start in fall 2016.

The successful applicant will develop and engineer efficient algorithms for analyzing biological high-throughput sequencing data. Supporting the lab's agenda, the successful candidate will employ tools and techniques from combinatorial optimization and machine learning to leverage large numbers of publicly available data sets. Translated into scalable and usable software, they will facilitate the systematic exploration of important biological or biomedical questions, such as the functional impact of alternative splicing.

The Canzar lab is embedded in the stimulating, interdisciplinary environment of the Graduate School of Quantitative Biosciences Munich (QBM), which integrates approaches ranging from bioinformatics and theoretical biophysics to biochemistry, molecular systems biology, and synthetic biology. The lab is housed in the new Research Center for Molecular Biosystems (BioSysM) at the life sciences campus Grosshadern/ Martinsried.

We are seeking motivated candidates with a degree in computer science, (applied) mathematics, or bioinformatics to join our lab.

To apply, send your application materials, including a motivation letter, your CV, and names of two referees in a single pdf file before 31 August 2016 to Stefan Canzar (canzar@ttic.edu), who can also supply further information about this position. The Canzar lab moves to LMU in September, our website is still at: http://ttic.uchicago.edu/~canzar/

 


 

The Hornung Lab at The Gene Center of the LMU is looking for a highly motivated


Bioinformatics Postdoc


Our interdisciplinary and international research group studies how our innate immune system is able to distinguish self from non-self at the molecular and cellular level. Our main methodological approach is the genetic dissection of immune cell signaling using genome engineering technologies (CRISPR/Cas9). We employ hypothesis-driven, candidate gene knock-out approaches, but also genome-wide unbiased screening campaigns. In this regard, our work relies on the analysis and interpretation of large-scale genomics and transcriptomics datasets.

To support and complement our efforts, we are looking for a highly motivated postdoctoral candidate to join our team.

Your qualifications:

  • You hold a Ph.D. in bioinformatics, computational biology, statistics, mathematics or a related field
  • You have proven experience in bioinformatics programming (e.g. R/Bioconductor, Python, Perl)
  • You have expert knowledge of bioinformatics software and algorithms for next-generation sequence analysis (i.e. alignment, quality assessment, variant detection, statistical inference)
  • Sound knowledge of statistics and data analysis
  • Strong problem-solving skills and scientific creativity
  • Very good communication and presentation skills in English.


What we offer:

  • You will have the opportunity to work on large-scale discovery projects using cutting-edge methodology and the latest sequencing technology
  • Exciting insight into molecular immunology and cell biology
  • The chance to work in a multidisciplinary and stimulating work environment
  • A position (E13-100%) that is available for four years with the possibility of extension.


The application should include a CV, a letter of motivation, proof of dissertation and contact information for three references. Please send the application to: hornung.office@genzentrum.lmu.de. Since we work with continuous selection and appointment, we encourage you to send your application as soon as possible. The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference.
Lab website: www.hornung.genzentrum.lmu.de

 


 

Master's Thesis Research Position

 

The Gene Center of the University of Munich (Ludwig-Maximilians-Universität München) carries out interdisciplinary research and teaching in the modern life sciences. The city of Munich is located in the south of Germany close to the Alps and offers a large variety of cultural events and leisure activities.

The Halic group at the Gene Center is happy to receive applications from highly motivated and enthusiastic researchers for Master’s thesis research.

The main focus of Halic group is on studying the mechanism of heterochromatin formation and of histone chaperoning. The research in our group is multifaceted and interdisciplinary in nature, ranging from genetics, systems biology and molecular biology to biochemistry and structural biology. This gives students a great opportunity to work in the field they find most exciting: yeast genetics, classical biochemistry, bioinformatics, or structural biology (either X-ray structural biology or cryo-electron microscopy).

If you are interested in joining our group or would like further information, please email Prof Dr Mario Halic at: halic@genzentrum.lmu.de

Handicapped candidates with equal qualifications will be given preference.

For information on the Gene Center, please visit www.genzentrum.lmu.de

 


 

Cryo-Electron Microscopy Postdoctoral and PhD Position  



We are looking for an enthusiastic graduate student and postdoctoral fellow to join Prof Mario Halic’s group (www.halic.genzentrum.lmu.de) at the Gene Center of the University of Munich. The main focus of the laboratory is on studying the mechanism of heterochromatin formation. We combine functional studies on the systemic level with genetic, biochemical and structural approaches, to work towards a mechanistic understanding of heterochromatin formation.

The successful candidate will employ cryo-EM to address fundamental questions in heterochromatin formation and spreading, for example, how the conserved heterochromatin protein 1 interacts with nucleosomes to facilitate heterochromatin spreading and compaction. We have already assembled multiple complexes involved in heterochromatin formation and collected preliminary cryo-EM data. The candidate will have access to existing samples produced by group members and would continue with some of the started projects.
The successful applicant will become part of a truly multidisciplinary group and will also benefit from colleagues using primarily genetic, genomic and biochemical approaches.

Handicapped candidates with equal qualifications will be given preference.

Enquiries should be directed to Mario Halic (halic@genzentrum.lmu.de).

 


 

Postdoctoral Position in the Klein Lab

 

Our interdisciplinary and international research group studies basic mechanisms of the development and function of the blood and the immune system using monogenetic diseases as paradigms. We are also interested in stem cell gene therapy. Our main focus lies on infantile primary immune deficiencies with special emphasis on the identification of novel genetic defects based on next generation sequencing (NGS).
Currently, we are offering a postdoc position funded by the European Research Council (ERC Advanced Grant).

 

Your profile:

  • Highly motivated scientist (PhD or MD) who shares our enthusiasm for science and research
  • Expertise in immunological, cell biological and genetic experimental techniques
  • Willingness to perform animal research and experience with mouse models
  • Very good English language skills
  • Flexibility, proactive attitude and interpersonal skills

 

Position:
We offer highly motivated scientist to participate in an ambitious research project at the interface between basic research and clinic in a stimulating interdisciplinary environment and an excellently equipped laboratory.
The position is initially limited to 2 years. The salary is according to TV-L. Handicapped candidates with equal qualifications will be given preference. We regret that we are unable to cover travel expenses for interviews. For further information please contact Dr. Regina Steck (089/4400-57977).

Application:
To apply, please send a PDF-file with the subject Name.First name:Postdoc to Regina.Steck@med.uni-muenchen.de or send your written application to Prof. Dr. Dr. Christoph Klein, Ãrztlicher Direktor, Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, LMU München, Lindwurmstr. 4, 80337 München, Germany.

 


 

Master and PhD Thesis in the Herzog Lab

 

Positions for a Master and a PhD thesis are immediately available in the research group of Franz Herzog at the Gene Center of the Ludwig Maximilians Universität München (LMU).
The group of Biological Mass Spectrometry laboratory (www.herzog.genzentrum.lmu.de) is especially interested in investigating the assembly of macromolecular protein complexes that are guiding the accurate distribution of genetic information to daughter cells during cell division. For the structural analysis we use chemical cross-linkers and identify the linked amino acid residues by mass spectrometry. The structural information is a distance measurement defined by the length of the cross-linker which allows to describe the subunit architecture of protein complexes. We will combine mass spectrometry with structural biology, biochemistry and cell biology to investigate the architecture of cellular protein structures and how they are assembled.

Your profile:
We are looking for highly motivated students who share our enthusiasm for interdisciplinary research combining mass spectrometry with structural and cell biology. Candidates must have practical experience in molecular biology and protein purification and a strong interest in cell division and protein biochemistry.

Research Environment:
The Gene Center is an institute of the LMU providing a dynamic, interactive and international scientific environment, located within the biomedical research campus in München-Martinsried. The research agenda of the Gene Center is focused on understanding how the genetic information stored on chromosomes is expressed and maintained in the cell. Disciplines represented at the Gene Center include structural biochemistry, genetics, cell biology and computational modeling of molecular systems.

Position:
The PhD position is initially limited to 2 years. The salary is according to the TV-L. The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference.

Please send your CV with a summary of previous research experience to Dr. Franz Herzog:
herzog@genzentrum.lmu.de

 


 

Technische Assistentin / Technischer Assistent in Molekularbiologie

für die Arbeitsgruppe Franz Herzog

 

Wir suchen für die Arbeitsgruppe Franz Herzog am Genzentrum der LMU München ab sofort eine technische Assistentin / einen technischen Assistent in Vollzeit.
Die Arbeitsgruppe beschäftigt sich mit der Etablierung von massenspektrometrischen Methoden für die strukturelle Aufklärung von makromolekularen Proteinkomplexen, die aus humanen Zellen oder aus Hefe aufgereinigt werden. Der Schwerpunkt des Labors liegt auf der Untersuchung von Proteinkomplexen, die entscheidend für die Zellteilung und die Chromatinstruktur verantwortlich sind. Die physiologische Rolle dieser Komplexe wird mit Hilfe von zellbiologischen und biochemischen Methoden charakterisiert.

Aufgaben:
Die technische Assistentin / der technische Assistent wird an konkreten Projekten arbeiten und maßgeblich für die Labororganisation verantwortlich sein. Zu den Hauptaufgaben zählen die Etablierung eines Zellkulturlabors in der Arbeitsgruppe, die Herstellung von humanen Zelllinien sowie die Entwicklung von Methoden zur Charakterisierung der Zelllinien mittels Immunofluoreszenz-Mikroskopie und Live Cell Imaging. Im Rahmen eines Projektes wird sie/er Proteine in humanen Zellen oder in Hefe exprimieren und diese mittels verschiedener chromatographischer Techniken aufreinigen. Weiter bietet diese Stelle die Möglichkeit, Erfahrung mit der massenspektrometrischen Analyse von Proteinen zu erwerben.

Profil:

  • Berufsabschluss als CTA, BTA, MTA oder vergleichbare Qualifikation (Dipl. Biol.)
  • Ausbildung in molekularbiologischen und biochemischen Arbeitsmethoden und deren selbständige Durchführung
  • Einschlägige Erfahrung in der Kultivierung von Säugetierzellen und im Labormanagement
  • Erfahrung mit Methoden der Mikroskopie sowie der Proteinexpression und -aufreinigung ist von Vorteil
  • Interesse an der massenspektrometrischen Analyse von Proteinen
  • Sehr gute Deutsch- und Englischkenntnisse
  • Selbständige Arbeitsweise

Ihr Arbeitsplatz befindet sich am Genzentrum der LMU auf dem Campus Großhadern und ist gut mit öffentlichen Verkehrsmitteln erreichbar. Wir bieten Ihnen eine interessante und verantwortungsvolle Tätigkeit mit guten Weiterbildungs- und Entwicklungsmöglichkeiten. Die Vergütung erfolgt nach TV-L abhängig von Ihren persönlichen Voraussetzungen. Schwerbehinderte Bewerber / Bewerberinnen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt. Die Bewerbung von Frauen wird begrüßt. Die LMU München ist um die Gleichstellung bemüht.
Bitte senden Sie Ihre Bewerbungsunterlagen ausschließlich in elektronischer Form an folgende Adresse: herzog@genzentrum.lmu.de
Weitere Informationen finden Sie unter: www.herzog.genzentrum.lmu.de.

 


 

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