Molecular Systems Biology 1

Time & Place:Attention! Due to unfortunate circumstances beyond our control it is currently unclear whether „Molecular Systems Biology“ can be offered during the 2017/2018 academic year. If you want to enroll in this extension topic, please announce yourself via email to This will help us make plans and we will keep you informed about the situation.
Dr. Stefan Canzar SC
Prof. Ulrike Gaul UG

This lecture course will familiarize the students with genome-wide data sets and the methods that are used to produce them. We will look at the genome, the transcriptome and study the processes of gene activation, from enhancers to promoters to transcription initiation, elongation and termination. We will also study the 3D architecture of active and repressive chromatin in the nucleus, post-transcriptional regulation and regulatory networks. The students will learn how to tackle genomic data by computational methods.

# PDF Date Topic Lecturer
1 19.10.2016 Introduction to molecular systems biology, NGS UG
2 26.10.2016 Genome, Transcriptome, Nucleosome UG
3 02.11.2016 Read mapping SC
4 09.11.2016 RNA quantification from RNA-Seq SC
5 16.11.2016 Open chromatin, TFs, and Enhancers UG
6 23.11.2016 Confidence intervals SC
7 30.11.2016 Chipseq with antibodies and Crispr UG
8 07.12.2016 Chipseq (peak calling and xx motif) SC
9 14.12.2016 Hypothesis testing SC
10 19.12.2016 NOTE: substitute lecture on ChIP Seq Analysis SC
11 ----- X-mas break -----
12 11.01.2017 Promoters UG
13 18.01.2017 Pol II initiation, elongation, termination UG
14 25.01.2017 3D architecture of repressive and active chromatin UG
15 01.02.2017 Post-transcriptional regulation UG
16 08.02.2017 Regulatory networks UG
17 15.02.2017 Exam - 2-4 pm, seminar room K2.045 in biosysM UG
Exams:Date 1, 15.02.2017 2:00pm

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