News

  • December 08, 2016

    Leibniz prize to Karl-Peter Hopfner

    Karl-Peter Hopfner is one of the 2017 Gottfried Wilhelm Leibniz prize winners!

  • November 30, 2016

    Stefan Canzar and Lucas Jae arrive at the Gene Center

    Two new junior group leaders have recently joined the Gene Center, Stefan Canzar and Lucas Jae. Stefan is interested in algorithmic computational biology and a QBM group leader. Before joining the Gene Center he was Rese...

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  • June 17, 2016

    Veit Hornung elected to Leopoldina

    The German National Academy of Sciences Leopoldina has elected Veit Hornung as a new member of its Microbiology and Immunology section. The Leopoldina was founded in 1652 and honors researchers for their outstanding scie...

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  • May 25, 2016

    GRK 1721 extended

    Our graduate training group "Integrated Analysis of Macromolecular Complexes and Hybrid Methods in Genome Biology" (GRK 1721; speaker: Karl-Peter Hopfner) will be funded by the DFG for another 4.5 years. The GRK 1721 bri...

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  • April 26, 2016

    Inauguration of new research building: Center for Molecular Biosystems (BioSysM)

    On 19 April 2016, we celebrated the official inauguration of the recently completed BioSysM research building. LMU President Prof. Bernd Huber, Dr. Ludwig Spaenle, Bavarian Minister for Science and Education, Stephan Mü...

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  • December 14, 2015

    Römer Awards 2015

    This year, Katharina Braunger, Stefan Arenz, Stephan Wickles, Lukas Bischoff and Agata Butryn from the Gene Center received Römer awards for their master/PhD theses. Since 2005 the Dr. Klaus Römer Foundation has been s...

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  • December 03, 2015

    M4 Award for Nadja Fenn, Karl-Peter Hopfner and Marion Subklewe

    Nadja Fenn, Karl-Peter Hopfner (Gene Center) and Marion Subklewe (University Hospital) have won one of five m4 Awards from the Bavarian Ministry of Economics for their project "A new antibody derivative that simultaneous...

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  • October 05, 2015

    Veit Hornung arrives at the Gene Center

    Veit Hornung, renowned immunologist and former director of the Institute of Molecular Medicine in Bonn, has been appointed Professor for Immunobiochemistry at the Department of Biochemistry. He has now started to move hi...

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  • August 13, 2015

    Vallee Young Investigator Award for Fabiana Perocchi

    Gene Center junior group leader Fabiana Perocchi is one of three recipients of the 2015 Vallee Young Investigator Award. The $250,000 Award donated by the Bert L and N Kuggie Vallee Foundation recognizes outstanding youn...

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  • March 31, 2015

    Franz Herzog awarded Human Frontier Science Program Grant

    Junior group leader Franz Herzog is part of an international team awarded a $ 900.000 research grant from the 2015 Human Frontier Science Program (HFSP), one of 31 proposals selected for funding from over one thousand ap...

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  • February 24, 2015

    BMBF-funded mitOmics consortium receives funding certificates from parliamentary state secretary Müller

    On 9 February 2015, Julien Gagneur and his collaborators Tobias Haack and Fabiana Perocchi presented their BMBF-funded mitOmics project to MP Dr. Wolfgang Stefinger and the parliamentary state secretary of the Federal Mi...

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  • February 02, 2015

    Ralph Neumüller arrives at the Gene Center

    Our new group leader Ralph Neumüller has just arrived at the Gene Center. His lab will be studying molecular mechanisms of cell growth regulation using a combination of genetics and systems biology approaches in Drosoph...

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  • December 22, 2014

    Karl-Peter Hopfner receives Max Planck Society membership

    The Max Planck Society has appointed Karl-Peter Hopfner as external scientific member of the Max Planck Institute of Biochemistry, Martinsried, in recognition of his outstanding work on the molecular mechanisms of genome maintenance.

  • December 09, 2014

    ERC Starting Grant to Franz Herzog

    Franz Herzog, leader of the junior research group “Biological Mass Spectrometry”, receives an ERC Starting Grant. The grant will support his studies on the structural reorganization of dividing cells and focuses on t...

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  • December 05, 2014

    Römer Ceremony 2014

    Since 2005, the Dr. Klaus Römer Foundation has been supporting research at the LMU Munich by awarding personal stipends to outstanding graduate students, postdocs and junior group leaders at the Departments of Biochemis...

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  • November 17, 2014

    Care-for-Rare Science Award to Petra Wendler

    Petra Wendler received the 2014 Care-for-Rare Science Award for her project on peroxisome biogenesis disorders. The prize honors outstanding research projects in the area of rare diseases affecting children and is endowe...

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  • October 30, 2014

    BMBF funding for Julian Gagneur and Fabiana Perocchi

    Together with Tobias Haack from the Helmholtz Zentrum München, Gene Center junior group leaders Julien Gagneur and Fabiana Perocchi have set up „mitOmics“, an initiative that – by analyzing genomes of patients wit...

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  • October 22, 2014

    Official inauguration of the Graduate School of Quantitative Biosciences (QBM)

    On October 20, 2014, we celebrated the official inauguration of the QBM Graduate School. LMU President Bernd Huber, Ulrich Hörlein from the Bavarian State Ministry for Science and Education, and the Speaker of QBM, Ulri...

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  • October 10, 2014

    New insights into the bacterial reaction to Erythromycin

    In a recent study, Daniel Wilson shows structural changes in the bacterial ribosome that occur with resistance to the antibiotic Erythromycin. They are imaged at extremely high resolution with the help of cryo-electron m...

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  • September 26, 2014

    Farewell Party for Patrick Cramer

    Patrick Cramer is leaving the Gene Center for the Max Planck Institute for Biophysical Chemistry in Göttingen. On September 26, we celebrated his outstanding achievements in science and science policy, which will have a...

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  • July 01, 2014

    Karl-Peter Hopfner elected to Leopoldina

    The German National Academy of Sciences Leopoldina has elected Karl-Peter Hopfner as a new member of its Biochemistry and Biophysics section. The Leopoldina was founded in 1652 and honors researchers for their outstandin...

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  • June 20, 2014

    Structure of the Vibrio cholerae type VI secretion system

    In a recent study, Petra Wendler and her team have investigated one of the special transport systems that bacteria use to deliver toxic proteins into host cells or competing bacteria, the type VI secretion system. The gr...

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  • September 01, 2012

    Three new group leaders at the Gene Center

    Three young scientists, Fabiana Perocchi, Franz Herzog, and Julien Gagneur have set up their labs at the Gene Center. Perocchi, who is funded by the Bavarian Research Network for Molecular Biosystems (BaySysNet) and by t...

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  • August 28, 2012

    ERC Starting Grant to Mario Halic

    Mario Halic receives an ERC Starting Grant, a highly endowed (€ 1.5 M for 5 years) and prestigious award for researchers in the early phase of their independent careers. The grant will support Halic's efforts to unders...

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  • July 31, 2012

    DNA damage sends small RNA signal

    In a recent study, Klaus Förstemann’s group could show that double strand breaks in the DNA result in the production of small interfering RNAs (siRNAs). The researchers could show that the siRNAs all derive from the r...

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  • June 22, 2012

    In pursuit of pathogenic factors

    In a recent study, Daniel Wilson’s group has identified the elusive factor that makes certain pathogenic bacteria more potent. The pathogenicity of these bacteria is strongly increased by the enzyme YfcM, which modifie...

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  • June 19, 2012

    Structure of DNA repair factor identified

    In a recent study, Karl-Peter Hopfner’s group has discovered the molecular mechanism underlying ATLD, an inherited neurodegenerative disease. The ATLD mutation affects the DNA repair complex MRN, which consists of the ...

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  • June 15, 2012

    Excellence day at LMU Munich

    Today, LMU Munich emerged as the most successful German university in the second round of the Excellence Initiative. All of its nine proposals – four graduate schools, four research clusters and the University’s over...

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  • June 01, 2012

    Diabetes – alarm signals in the blood

    In a recent study, Eckhard Wolf’s group developed a transgenic pig that models the pre-diabetic phase of the disease. In collaboration with the Helmholtz Center Munich, the scientists identified biomarkers whose concen...

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  • May 14, 2012

    First BioSysNet Meeting at the LMU Gene Center

    The new Bavarian Research Network for Molecular Biosystems (BioSysNet) held its inaugural symposium at the Gene Center today. Following welcoming remarks by Science Minister Dr. Wolfgang Heubisch, the participating resea...

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  • May 09, 2012

    Ulrike Gaul elected to EMBO

    Ulrike Gaul has been elected member of the European Molecular Biology Organization (EMBO) in recognition of her pioneering work in developmental systems biology.

  • April 17, 2012

    Patrick Cramer receives Federal Order of Merit

    Patrick Cramer received the Federal Order of Merit (Bundesverdienstkreuz am Bande des Verdienstordens der Bundesrepublik Deutschland) for his groundbreaking work on transcription. The Director of the Gene Center was also...

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  • February 23, 2012

    Cells practice sustainability – conserved mechanism of ribosomal recycling

    In a recent study, Roland Beckmann’s group has investigated the recycling of ribosomes, a key phase in ribosome-driven protein biosynthesis. For the first time, the researchers were able to visualize the binding of a k...

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  • January 05, 2012

    BioSysNet funds four new junior research groups in Systems Biology

    The Bavarian State Ministry of Sciences has announced funding for four independent junior research groups to inaugurate the new Bavarian Research Network for Molecular Biosystems (BioSysNet). Each group will receive 1.5 ...

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  • December 27, 2011

    Improved algorithm for sequence analysis of proteins

    In a recent study, Johannes Söding’s group has introduced a new computer algorithm, HHblits, which detects sequence similarities in proteins much better and faster than the commonly used PSI-BLAST. Nature Methods December 25, 2011.

  • November 16, 2011

    Beckmann receives ERC Advanced Investigator Grant

    Roland Beckmann received an Advanced Investigator Grant from the European Research Council. These lucrative and highly competitive grants are awarded to European researchers based on their outstanding scientific achievem...

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  • October 13, 2011

    Wolf among the most highly cited reproduction biologists

    Eckhard Wolf is the second-most highly cited reproduction biologist in Germany, Austria and Switzerland, according to an analysis by the monthly ‘Laborjournal’ (www.laborjournal.de).

  • September 26, 2011

    How genes are transcribed in mitochondria

    In a recent study, Patrick Cramer’s group, in collaboration with Dmitry Temiakov at UMDNJ, has described the first three-dimensional structure of the human mitochondrial RNA-polymerase. Interestingly, the structure sh...

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  • July 18, 2011

    m4 award to LMU and University of Erlangen teams for leukemia research

    Karl-Peter Hopfner, together with Fuat Oduncu (Medical Clinic, LMU) and Georg Fey (Friedrich-Alexander-University Erlangen), received an m4 award in the amount of €500,000 for their proposal to develop antibody derivat...

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  • July 07, 2011

    Molecular corkscrew knows the drill

    In a recent study, Karl-Peter Hopfner's group has investigated how Swi2/Snf2 remodelers modulate protein-DNA interactions. They analyzed the structure and function of Modifier of Transcription 1 (Mot1), a simple member o...

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  • June 21, 2011

    How to make stripes

    Recent research from Ulrike Gaul's lab sheds new light on how periodicity is generated in animal body plans. Using a combination of computational and experimental approaches, the scientists examine the complex transcript...

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  • June 09, 2011

    When ribosomes get stuck - watching the demise of defect mRNAs

    A recent study by Roland Beckmann's group provided new insight into the demise of mRNAs stalled on ribosomes, a process called Nogo decay and mediated by the factors Dom34 and Hbs1. Using cryo electron microscopy, they ...

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  • May 18, 2011

    Protein complex Prp19 plays dual role in control of gene expression

    New research from Katja Strässer's group shows how the TREX complex, which couples transcription of mRNAs to their export into the cytoplasm, is recruited to actively transcribed genes. They could demonstrate that the p...

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  • April 20, 2011

    How molecules find the right place at the right time

    In a recent study, Dierck Niessing's group made an important contribution to understanding the underlying principles of messenger RNA transport within the cell. Using a combination of biochemical, biophysical and in viv...

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  • April 18, 2011

    How proteins are integrated into the plasma membrane – a 3D view

    In a recent study, Roland Beckmann’s group introduces a new method by which the integration of proteins into membranes can be investigated. During translation, ribosomes settle on a membrane-spanning channel into which...

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  • April 01, 2011

    Solving the crystal structure of a key factor in DNA repair

    The most dangerous damage to genomic DNA are double strand breaks. In a recent study, Karl-Peter Hopfner’s group has solved the crystal structure of the MR complex, which plays a central role in recognizing these break...

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  • February 24, 2011

    How cells overcome transcription blockage

    In a recent study, Patrick Cramer’s group unravels the structural basis of RNA Polymerase II backtracking, arrest and reactivation (Nature 471:249-43).

  • January 26, 2011

    Viruses spoiling their hosts’ innate immune response

    Co-evolution with their hosts made viruses experts in manipulating the immune system of their hosts. In two recent studies, the group of Karl-Klaus Conzelmann elucidates key mechanisms of immune evasion by two different ...

    Co-evolution with their hosts made viruses experts in manipulating the immune system of their hosts. In two recent studies, the group of Karl-Klaus Conzelmann elucidates key mechanisms of immune evasion by two different viruses, the neurotropic rabies virus and the haematotropic measles virus. While the rabies virus simply counteracts expression and function of interferon, a powerful antiviral and immune-stimulatory cytokine, the measles virus also interferes with the activity of the transcription factor NF-kB, which governs both innate immune responses and differentiation of immune cells (J Virol XXX, 2011; J Virol 85: 842-52).  

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  • January 04, 2011

    Dynamic transcriptome analysis measures mRNA turnover

    In a recent study, Achim Tresch’s and Patrick Cramer’s groups have collaboratively developed a novel method, dynamic transcriptome analysis, to determine messenger RNA synthesis and decay rates on a genome-wide level...

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  • December 16, 2010

    MP Seehofer signs off on funding for systems biology

    Bavarian Minister President Seehofer and the State Parliament passed the state budget for the coming 2 years, which commits 13.6 Mio € to establish the new Research Center for Molecular Biosystems and 18.1 Mio € to t...

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  • December 14, 2010

    Cramer receives ERC Advanced Investigator Grant

    Patrick Cramer has received an Advanced Investigator Grant from the European Research Council. These lucrative and highly competitive grants are awarded to European researchers based on their outstanding scientific achie...

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  • December 02, 2010

    How tRNAs move through the ribosome during translation

    During translation, tRNAs move through the ribosome by a process called translocation, which is catalyzed by the elongation factor EF-G. By utilizing the antibiotic fusidic acid, a recent study by Daniel Wilson’s group...

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  • November 23, 2010

    Wilson receives EMBO Young Investigator Award

    Daniel Wilson has been honored with the prestigious EMBO Young Investigator Award for his work to improve the design of antibiotics based on the structural analysis of bacterial ribosomes.

  • November 19, 2010

    Transcription factor implicated in DNA repair

    In a recent study, Katja Strässer’s group showed that the transcription factor Bur1-Bur2, which is known to interact with a protein complex that couples transcription with RNA export (TREX), also plays a role in DNA r...

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  • October 27, 2010

    Beckmann and Hopfner become EMBO Members

    Professors Karl-Peter Hopfner and Roland Beckmann have been elected EMBO members for their outstanding work on the molecular mechanisms of genome maintenance and protein translation, respectively.

  • October 08, 2010

    Protein synthesis can be blocked specifically

    Translation of particular polypeptide chains leads to translational stalling, which is used by eukaryotes to repress the translation of downstream genes. In a recent study by Roland Beckmann’s and Daniel Wilson’s gro...

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  • October 01, 2010

    How tRNA production is turned off

    In a recent study, Patrick Cramer’s group has elucidated how one of the key engines of gene expression, RNA polymerase III, is inhibited when cells are under stress. Using a combination of structural biology and bioch...

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  • September 28, 2010

    Beckmann elected to Leopoldina

    The German Academy of Natural Scientists Leopoldina has elected Professor Roland Beckmann as a new member of its Biochemistry and Biophysics section. The Leopoldina was founded in 1652 and honors researchers for their ou...

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  • July 05, 2010

    Federal Funding secured for BioSysM Research Building

    The German Science Council (Wissenschaftsrat) has recommended funding the construction of a new research building ‘Molecular Biosystems Munich’ on the life sciences campus Großhadern/Martinsried. This new building s...

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  • May 28, 2010

    New insights into the function of antibiotics

    Macrolide antibiotics bind within the ribosomal tunnel and prevent elongation of the nascent polypeptide chain. In a recent study, Daniel Wilson’s group provides evidence that the sequence of the polypeptide influences...

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  • May 25, 2010

    Protein linking the most important steps in gene expression

    In a recent publication, Katja Strässer’s group has studied the RNA binding protein Sro 9, which was known to play a complex role in gene expression. They demonstrated that Sro9 is recruited to actively transcribed g...

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  • February 07, 2010

    Ribosomal tunnel restricts α-helix formation to exit

    In a recent study, Roland Beckmann’s group visualizes the nascent polypeptide chains with high α-helical propensity within the ribosomal tunnel. Interestingly, helix formation appears to be restricted to defined regio...

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  • January 27, 2010

    Evolution of bacterial outer membrane proteins

    In a recent study, Johannes Söding’s group reconstructed the evolutionary origin of the main class of bacterial outer membrane proteins. By applying various advanced sequence search methods developed by the authors, t...

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  • January 17, 2010

    Nanobodies change the form and function of proteins

    In a recent collaborative study, Karl-Peter Hopfner’s group has shown that nanobodies, small single domain antibodies, modulate the conformation and spectral properties of GFP. Through subtle changes in the chromophore...

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  • December 04, 2009

    Caught in translation

    In a recent double feature, Roland Beckmann’s group has studied different aspects of nascent translation. In all organisms, the translation of secretory and membrane proteins can be directly coupled to the translocatio...

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  • October 30, 2009

    Novel antibiotic lead compounds identified

    The emergence of multi-drug resistant bacterial strains underscores the urgent need for the development of novel antimicrobial agents. In a recent study by Daniel Wilson’s group, a variety of high-throughput translatio...

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  • October 23, 2009

    New protein structure involved in neurodegeneration

    In a recent publication, Dierk Niessing’s group has solved the x-ray structure of Pur-alpha, a protein which binds to CGG repeats in messenger RNA and is a key factor in fragile X-Syndrome, one of the most common genet...

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  • October 09, 2009

    Finding the transcription start site of a gene

    In a recent study, Patrick Cramer’s group has developed a model for transcription initiation from the promoter of a protein-coding gene in yeast. Using a combination of structural biology, biochemistry and genetics, th...

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  • October 07, 2009

    Small RNAs keep selfish genetic elements under control

    Control of selfish genetic elements is essential in the germline, however, their activity has to be restrained in somatic cells also. In Drosophila, a small RNA-based ‘immune system’ called endo-siRNAs is in charge o...

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  • October 01, 2009

    Petra Wendler arrives at the Gene Center

    Petra Wendler, a Fellow of the Emmy Noether Program of the DFG, has just arrived at the Gene Center. Her lab will be studying the mechanisms of force generation in molecular motor proteins of the AAA+ family, such as the...

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  • July 29, 2009

    microRNA has multiple roles in germline development

    In a recent study, Ulrike Gaul’s group has shown a surprisingly broad role for a single microRNA, miR-184, in flies. They find that miR-184 is required maternally for stem cell differentiation in the ovaries, as well a...

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  • June 01, 2009

    Gaul lab arrives at the Gene Center

    Ulrike Gaul, recipient of an Alexander von Humboldt Professorship in 2008 and newly appointed Professor of Organismic Biochemistry at the Department of Biochemistry, arrives at the Gene Center with her group – and a fe...

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  • April 10, 2009

    Protein disaggregase Hsp104 on the move

    In a recent study, Petra Wendler’s group presents cryo EM reconstructions of the protein remodeling complex Hsp104 in different functional states. The structures reveal large, nucleotide-dependent domain rearrangements...

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  • February 23, 2009

    Improved sequence analysis of genes and proteins

    In a recent study, Johannes Söding’s group has introduced a novel computational method for finding remote homologies in protein and DNA sequences. Their algorithm searches sequences databases at the same speed as othe...

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  • February 20, 2009

    How human cells sense RNA viral infections

    How human cells distinguish between invading viral RNA and their own cytoplasmic messenger RNA is not well understood. In a recent collaborative study, Karl-Peter Hopfner’s group has shown that the cytosolic multidomai...

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  • January 08, 2009

    Cramer receives Ernst-Jung Research Award

    Patrick Cramer receives the Ernst-Jung Research Award for his outstanding work on transcription. This annual Prize was established in 1967 by the Hamburg merchant Ernst Jung and is awarded for ground-breaking medical research.

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